Modification chimique du chitosane extrait des plumes de calamar et application dans la formulation de nanogels

Abstract

In the constantly expanding pharmaceutical field, new innovative, effective, rapid and easy-to-use forms are continually being developed. The aim of this study is to extract a raw material that is in great demand in the pharmaceutical industry and that has until now been imported from abroad: chitosan, a natural polysaccharide that is extremely expensive and has proved to have numerous therapeutic virtues. It was extracted from squid feathers, a marine by-product. In order to give the extracted biopolymer new functionalities, oxidation proved to be an interesting alternative, confirmed by spectroscopic analyses such as FTIR, which highlighted the presence of the new oxidised group. The new oxidised group also improved solubility and antibacterial activity. The nanogels formulated under optimised conditions using extracted, oxidised and commercial chitosan as the active ingredient and also as an excipient showed non-Newtonian behaviour in rheological tests and their textures were comparable to their commercial counterparts, with good stability over time justified by a Zeta potential in the region of -30 Mv and a particle size of between 100 and 500 nm.