Résumé:
Hypertension, is a major risk factor for cardiovascular diseases. Rapidly lowering blood
pressure to normal levels is effective in reducing the risks of these diseases. Therefore, the
oral administration of drugs through thin films is a better alternative in such cases. This
method also offers an alternative to conventional treatments for inflammation, providing
improved bioavailability and easier administration.
In this study, the development of Oral Dissolving Films (ODF) using the solvent
casting/evaporation method was explored for administering acebutolol hydrochloride, an
antihypertensive drug, and diclofenac sodium, an anti-inflammatory drug. Physicochemical
characterizations of the ODFs revealed an increase in the dissolution rate and extent of
acebutolol and diclofenac.
The oral films are evaluated for dimensions, disintegration, tensile strength, stability and
folding endurance. These ODFs have numerous applications, such as taste masking and
immediate release. Additionally, these systems can be easily applied on their own.
