Résumé:
In the constantly expanding pharmaceutical field, new innovative, effective, rapid and
easy-to-use forms are continually being developed. The aim of this study is to extract a raw
material that is in great demand in the pharmaceutical industry and that has until now been
imported from abroad: chitosan, a natural polysaccharide that is extremely expensive and has
proved to have numerous therapeutic virtues.
It was extracted from squid feathers, a marine by-product. In order to give the extracted
biopolymer new functionalities, oxidation proved to be an interesting alternative, confirmed
by spectroscopic analyses such as FTIR, which highlighted the presence of the new oxidised
group. The new oxidised group also improved solubility and antibacterial activity.
The nanogels formulated under optimised conditions using extracted, oxidised and
commercial chitosan as the active ingredient and also as an excipient showed non-Newtonian
behaviour in rheological tests and their textures were comparable to their commercial
counterparts, with good stability over time justified by a Zeta potential in the region of -30 Mv
and a particle size of between 100 and 500 nm.
